Relative Sensitivity of Parkin and Other Cysteine-containing Enzymes to Stress-induced Solubility Alterations
نویسندگان
چکیده
منابع مشابه
Relative sensitivity of parkin and other cysteine-containing enzymes to stress-induced solubility alterations.
Loss of parkin function is a predominant cause of familial Parkinsonism. Emerging evidence also suggests that parkin expression variability may confer a risk for sporadic Parkinson disease. We have recently demonstrated that a wide variety of Parkinson disease-linked stressors, including dopamine (DA), induce parkin solubility alterations and promote its aggregation within the cell, a phenomeno...
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In this paper we introduce the concept of α-commutator which its definition is based on generalized conjugate classes. With this notion, α-nilpotent groups, α-solvable groups, nilpotency and solvability of groups related to the automorphism are defined. N(G) and S(G) are the set of all nilpotency classes and the set of all solvability classes for the group G with respect to different automorphi...
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in this paper we introduce the concept of α-commutator which its definition is based on generalized conjugate classes. with this notion, α-nilpotent groups, α-solvable groups, nilpotency and solvability of groups related to the automorphism are defined. n(g) and s(g) are the set of all nilpotency classes and the set of all solvability classes for the group g with respect to different automorphi...
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Mutations in the gene parkin in humans (PARK2) are responsible for a large number of familial cases of autosomal-recessive Parkinson disease. We have isolated a Drosophila homolog of human PARK2 and characterized its expression and null phenotype. parkin null flies have 30% lower mass than wild-type controls which is in part accounted for by a reduced cell size and number. In addition, these fl...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2007
ISSN: 0021-9258
DOI: 10.1074/jbc.m609466200